VueScan is compatible with the HP ScanJet 5200 on Windows x86, Windows x64, Windows RT, Windows 10 ARM, Mac OS X and Linux. If you're using Windows and you've installed a driver, VueScan's built-in drivers won't conflict with this.

If you haven't installed a Windows driver for this scanner, VueScan will automatically install a driver. You can use this scanner on Mac OS X and Linux without installing any other software. On Linux, you need to set up libusb device protections. HP sold this scanner in some countries as the ScanJet 5200c.

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